Short answer: Usually no. A spouse’s general-purpose FSA can cover your expenses, which counts as disqualifying coverage and makes you ineligible to contribute to an HSA, even if you’re not enrolled in the FSA yourself.
HSA eligibility looks at all the coverage that can pay your medical bills, including a spouse’s. Because a general-purpose health FSA can reimburse the expenses of the employee’s spouse and dependents, your spouse’s FSA is considered disqualifying coverage for you, blocking your HSA contributions for that period. The fix is for the spouse to choose a limited-purpose FSA (dental/vision only) instead, which preserves your HSA eligibility. This is one of the most common accidental HSA-eligibility mistakes.